Checkpoints are only available by retrying the mission after it has been previously failed - going to the mission start point begins the mission from scratch.

The most prominent of these additions is the availability of mid-mission checkpoints, which can spare the player repeated trips to a given location in order to trigger and replay a failed mission again - an often criticised aspect of the Grand Theft Auto series. The game also features new additions, some in regard to Johnny's connection to the Lost MC, and some minor changes. It features similar gameplay to that of Grand Theft Auto IV, and takes place in the same setting of Liberty City, the game only features around a third of the number of missions from that game, as was stated in an interview between IGN and the president of Rockstar North, which thus places the amount of time to complete it at approximately 10–15 hours, depending on how focused the player is on the storyline. Grand Theft Auto IV: The Lost and Damned is an action-adventure game set in an open world environment and played from a third-person perspective. The game received highly positive reviews upon release, and is retrospectively considered to be among the best downloadable content packs on record. The episode portrays Johnny's perspective in the storylines of the blood diamonds and heroin, which are depicted from the other protagonists' perspectives in Grand Theft Auto IV and The Ballad of Gay Tony.

The main storyline of the episode focuses on Johnny's efforts to keep the chapter running, while dealing with internal conflicts, gang warfare, drug running, and various enemies. Set concurrently with the events of Grand Theft Auto IV and The Ballad of Gay Tony, The Lost and Damned follows the exploits of Johnny Klebitz, vice-president of the Liberty City chapter of The Lost MC, a motorcycle club which, along with himself, feature in a number of missions in both games. Microsoft added Episodes from Liberty City to its backwards compatibility list for Xbox One platforms in February 2017. The package also includes the second Grand Theft Auto IV expansion, The Ballad of Gay Tony, and does not require the base game to be played. The game was released individually for the Xbox 360 on 17 February 2009, and as part of the disc-based package Grand Theft Auto: Episodes from Liberty City for PlayStation 3 and Windows on 13 April 2010. Grand Theft Auto IV: The Lost and Damned is the first of two episodic expansion packs of the 2008 video game Grand Theft Auto IV, developed by Rockstar North and published by Rockstar Games.

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